Technology

We are building an integrated MS-based workflow for intact, native complexes, i.e. "complex-down" characterization, with state-of-the-art instrumentation and software that can answer structural biology questions. An integrated workflow for native MS will define the m/z of the intact complex, m/z of subcomplexes, stoichiometry, heterogeneity, connectivity of partners, topology, conformational diversity, collision cross sections, and relative subunit binding strengths of intact, native protein complexes with high sensitivity and throughput. The workflow will be created with the integration of five Technology and Research Development projects (TR&Ds).

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TRD Info: 
Improved Design and Integration of SID Technology for Multiple MS Platforms
TRD Info: 
A "Next Generation" High Resolution Native ESI-Ion Mobility-Mass Spectrometer
TRD Info: 
Hybrid SID, IM, and UVPD Methods for Complex-Down MS of Protein Complexes
TRD Info: 
Chromatographic and Electrophoretic Separations Optimized for Native MS
TRD Info: 
Computational Tools for Protein Complex Structure Prediction from MS Data