National Resource for
Native MS-Guided Structural Biology

About Us

“Characterizing protein complex structures, their interactions, and how they relate to biological functions is key to identifying, preventing and treating disease. The Resource for Native MS-guided Structural Biology will drive the development of innovative scientific instrumentation and computational tools to reveal the complex chemical structures of biomedically relevant molecules. We invite you to explore our website to learn more about our developing technologies and opportunities for training and collaboration.”

–Vicki Wysocki, Director

The Resource for Native Mass Spectrometry Guided Structural Biology (nMS→SB) was established in 2018 with a 6.8M P41 grant from the NIH National Institute of General Medical Sciences. As a national Biomedical Technology Research Resource, our purpose is to develop and disseminate novel technologies throughout the broader biomedical research community. Our mission is to develop improved native MS as a routine tool and disseminate the technology to the biomedical research community through vendor partnerships and training. The Resource works with investigators across the nation and globe on challenging biomedical projects ranging from viral hemorrhagic fevers and HIV to cataract formation and neurological disorders.


The Ohio State UniversityTexas A&M UniversityWest Virginia University

Technology Research and Development

We are building an integrated MS-based workflow for intact, native complexes, with state-of-the-art instrumentation and software that can answer the desired structural biology questions.



Collaboration drives all aspects of the Resource. Advancing technologies and their applications for structural biology is fostered by collaborations with Industry Partners, Software Consultants, National Lab Partners, and researchers from across the globe.     



A leadership team coordinates all activities of the Resource, under the direction of Vicki Wysocki, with Resource personnel consisting of PhD scientists, postdoctoral researchers, and graduate students from The Ohio State University, Texas A&M, and West Virginia University.



Advanced instrumentation, software tools, and protocols allow biomedical investigators to make progress on structural biology problems with lower sample amounts, more rapidly, and with more rigor than currently possible.



Publications include advances in our technology research and development projects, as well as research with our collaborators in Driving Biomedical Projects (DBPs) and Collaboration and Service (C&S) projects.



Dissemination throughout the broader biomedical research community is fostered with training opportunities to educate potential users in state-of-the-art and cutting-edge technologies that might solve their macromolecular characterization problems.