Collaboration drives all aspects of the Resource. Technology Research and Development is fostered by collaborations with Industry and Technology Partners, Software Consultants, National Lab Partners, and researchers from across the nation and globe. Driving Biomedical Projects (DBPs) have both biomedical significance and substantial technical structural characterization challenges. DBPs are integrated with the Technology Research and Development (TR&D) projects and serve as the drivers and testbeds of developing technologies. Collaboration and Service (C&S) Projects show investigators how developed technologies can begin to answer their questions for structural biology.